JABADO LAB PAST MEMBERS

Josiane Alves França, MSc

Josiane was an internship student in the Jabado Lab from December 2018 to October 2019. She is a PhD student in Molecular Medicine at Federal University of Minas Gerais (UFMG), Brazil, focusing in the molecular biology and pathology field. She completed her Master's degree in the same area at UFMG in 2016 and her BSc in Biomedicine at FUMEC, Brazil. 

Maud Hulswit, BSc

Maud was in the Jabado lab from February to July 2019 as a Master's student in Oncology from the Free University of Amsterdam. As she completed her bachelors in Neuroscience, she realised the field she was most interested in was that of Neuro-oncology. During her master program a special interest in epigenetics developed. Her project  in the Jabado lab involved defining the cell-of-origin in pediatric high-grade Gliomas bearing the K27M mutation by researching the H3K27me3 marking on developmental genes. 

Tiffany Leung

Tiffany was a Co-op student from University of British Columbia where she is completing her Bachelor's Degree in the Department of Microbiology and Immunology. She assisted Melissa and Michele with their experiments, such as Western Blots, qPCR and drug assays. Outside the lab, she loves traveling, but she also loves to stay at home and watch movies. Most importantly, she is a foodie. =) 

Tianna Sihota

Tianna was a Co-op placement student from the University of British Columbia, where she is pursuing a Bachelor's Degree in the Department of Microbiology and Immunology. Under the supervision of Carol and Sima she assisted with various projects, developing her understanding of techniques in molecular biology and genetics. When not in the lab, she enjoys reading, listening to music and traveling.

Brice Poreau, MD

Graduated from the military academy of Saint-Cyr (France), Brice Poreau then moved to medicine and science. He obtained his MD (medical genetics) in 2014 and completed his PhD in cell biology in 2017 on the role of huntingtin in muscle. He obtained a fellowship at Jabado's lab on multiple applications of single cell RNA sequencing.

He is also the co-founder of an NGO - Moyen Chari - working in Africa. He enjoys theater, jazz and flying.

Melissa McConechy, PhD

Melissa was a postdoctoral fellow in the Jabado lab from September 2015 to August 2018. She completed her Ph.D. in the Department of Pathology and Laboratory Medicine at the University of British Columbia, where she identified subtype- specific mutations of endometrial and ovarian cancers. She was also involved in projects that aimed to improve diagnosis and inform prognosis for women with these gynecological cancers. In the Jabado lab, Melissa was involved in deciphering the three-dimensional chromatin conformation of pediatric high-grade gliomas using Hi-C (High Throughput Chromatin Conformation Capture). Melissa’s other research interests involve using next generation sequencing technology, and novel methodology developments to further improve our understanding of these pediatric brain cancers. To undergo this research, she was awarded the prestigious CIHR Banting postdoctoral fellowship.

Outside of research Melissa enjoys being in the outdoors with her family. She loves hiking, biking, playing beach volleyball, snowboarding and traveling. She is currently a senior scientist at the company Contextual Genomics in Vancouver.

Carolina Cavalieri Gomes, DDS, MSc, PhD

Carolina is an Associate Professor at the Department of Basic Pathology at Universidade Federal de Minas Gerais (UFMG) in Brazil. She was a visiting professor in Dr. Jabado’s lab from July 2017 to June 2018. She obtained a degree in Dentistry (DDS), a MSc in Oral Pathology and a PhD in Molecular Medicine at UFMG, Brazil. She is a Molecular Pathologist and her research focus is the molecular pathogenesis of benign and malignant oral tumors and the malignant transformation of potentially malignant oral lesions (oral leukoplakia). Her joint project with Dr. Jabado involved the identification and functional characterization of molecular drivers of bone lesions. Science is her passion.

Ricardo Santiago Gomez, DDS, MSc, PhD

Ricardo was a visiting Professor in the Jabado lab from July 2017 to June 2018. He obtained his DDS and MSc degrees in Pathology at the Federal University of Minas Gerais (UFMG) and completed his Ph.D. in Oral Pathology at the University of São Paulo (USP), Brazil. He is a Full Professor at the Department of Oral Pathology in UFMG, Brazil.  He held positions of the Dean of Graduate Studies of the UFMG (2009-2014) and Dean of the School of Dentistry (2004-2008). He is Associate Editor of the Journal of Oral Pathology & Medicine and his main research interest is the molecular pathogenesis of tumors. He loves playing the trumpet and saxophone.

Jad Belle, BSc, MSc

Jad obtained his BSc in Biochemistry (2011) and MSc in Physiology (2014) from McGill University. He joined the Jabado Lab in 2016 as a Research Assistant. During his brief tenure, he optimized chromatin immunoprecipitation protocols and used them to profile transcription factor binding in several patient-derived tumor cell lines. He is currently pursuing MD/PhD training at Washington University School of Medicine and remains interested in cancer genetics and biology.

Erin (Xiaodan) Yang

Erin spent 2017 in the Jabado lab as a Co-op placement student as part of her Bachelor’s Degree in the Department of Cell Biology and Genetics at the University of British Columbia. While here, she assisted with multiple projects to varying degrees. She was also the resident graphic designer, helping to produce figures for the lab. She is an avid visual artist, plant-keeper, and badminton player.

Jonathan Pratt, PhD

Jonathan is from Montreal and he completed all his graduate studies at UQAM. After his BSc, Jonathan obtained a PhD in biochemistry. He studied the molecular mechanisms involved in the survival of glioblastoma. During his Ph.D, Jonathan won many prizes and distinctions like the Lieutenant Governor’s Youth Medal, the FRQNT Étudiants-chercheurs étoiles Award and the 2016 Best student research Award (UQAM-Faculty of sciences). In his 1-year of postdoctoral fellowship, Dr Pratt worked on identifying checkpoint mutations in genes involved in autoimmune diseases and brain cancers and investigating their effects on the protein phenotype. Jonathan has done a lot of volunteering, working on projects for the Canadian Red Cross, the Lifesaving society and the UQAM graduate students committee. Jonathan is temporarily working as a lifeguard/water safety instructor and is looking to pursue a MBA in sciences and engineering.

Elvis Valera, MD

Elvis Valera is a Pediatric Oncologist from Brazil who completed postdoctoral training in the Jabado lab, focusing mainly on biomarkers (cell-free DNA and tumor-free DNA) of brain tumors in plasma, CSF and urine. His main areas of interest are new genetic syndromes predisposing to brain cancer in children and the radiosensitizing effect of new drugs for treating brain cancer.

Elvis enjoys riding the bike with his family and barbecues on the weekends with friends.

Yelu Zhang, BSc

Yelu started at the Jabado lab in 2013 as an undergraduate student working on the detection of Glioblastoma Multiforme (GBM) biomarkers in biofluids and microvesicles. She then completed a research project from 2015-2016 focused on generating cell line models of Giant Cell Tumor of the Bone using CRISPR-Cas9. Doing research at the Jabado lab was one of Yelu's favourite undergrad experiences (and she thinks it's the best lab ever). Yelu graduated from McGIll in 2016 with a B.Sc. in honours anatomy and cell biology and is currently a medical student at Boston University. She likes yoga, coffee, bollywood dancing, singing with her school's a capella group, and playing with furry animals.

Tenzin Gayden, MSc, PhD

Tenzin obtained his PhD in population genetics from Florida International University in Miami and decided to move to a slightly different climate and brace himself for Canadian Winters. He was a postdoctoral fellow in the Jabado Lab between 2012 and 2016 working on the genetics of pediatric brain tumors and analyzing Next Generation Sequencing data for every single project in the group. He was recently appointed as project manager for the Montreal subdivision of the Terry Fox PROFYLE project (PRecision Oncology For Young PeopLE).

Eef Harmsen, PhD

Eef was project manager for the Genome Canada ICHANGE project from 2014 to 2016. As a native of the Netherlands, he obtained a MSc in biochemical engineering (Delft) and a PhD in cardiac biochemistry (Rotterdam). Via Oxford (UK), he landed in Calgary in 1987 and spent a few years in Ottawa before settling in Montreal. From 2001 he was project manager of large scale projects funded by Genome Canada and Genome Quebec. He enjoyed working with Nada and her team while learning quite a bit about epigenetics and brains. ICHANGE was his last project and since retirement spends his time at the BBQ, gym and reading.

Noha Gerges, PhD

After completing her degree in Molecular Biology and Genetics from the University of Guelph, Noha joined the Jabado lab to pursue a PhD in cancer genetics in 2008. She studied the genetics and proteomics of several pediatric brain tumors and received her PhD in 2014. For the three years following that, Noha was the Program Manager for the Child Health and Human Development Program at the Research Institute of the MUHC. She is now a Mitacs Business Development Specialist for the Healthy Brains for Healthy Lives initiative at McGill. In her free time, Noha runs a side bakery where she spends time trying to come up with new and exciting recipes, travels as much as she can, designs websites, and is always on the hunt for new and exciting things to do in Montreal.

Adam Fontebasso, MDCM (’17), PhD (’15)

Originally from Montreal, QC, Adam completed his PhD studies in the Jabado lab while enrolled in the MD-PhD program at McGill University. During his four years in the lab between January 2011 to December 2014, he worked with genomic and epigenomic data of childhood brain tumors, with a specific focus on pediatric high- and low-grade gliomas. He was able to contribute to the characterization of histone mutations in pediatric glioblastoma as well as mutations in ACVR1 in deadly pediatric diffuse intrinsic pontine gliomas (DIPGs). Adam also maintained an interest in pilocytic astrocytomas, the most common CNS tumor of childhood, and was able to contribute to projects characterizing age-related aneuploidy as an important mechanism in these tumors.

Following his PhD studies, Adam went on to complete his medical degree in 2017 at McGill and is currently completing his residency training in General Surgery at the University of Ottawa and maintains his clinical and research interests in childhood cancer and congenital diseases.

Nisreen Samir Ibrahim, GrDip

Nisreen obtained her BSc degree in Biochemistry from Ain Shams University in Egypt and completed her graduate diploma in biotechnology and genomics at Concordia University. She subsequently joined The Jabado lab for a Master’s degree between 2012 and 2015. The aim of her project was to generate novel experimental models using the sleeping beauty (SB) transposon system to understand the role of histone H3.3 mutations in the genesis of brain tumors. This system allows integrating mutations in histone H3.3 (K27M and G34R) with concomitant down-regulation of TP53 and Atrx to dissect the mechanisms underlying the development of brain tumors.

She is presently doing her PhD in the lab of Dr. Peter Metrakos in the Department of Anatomy and Cell Biology at McGill University.

Dong-Anh Khuong Quang, MD, PhD

Dong Anh was in the lab from 2008 to 2013 where she completed a Master’s degree in Oncology (University Paris-Sud 11) and a PhD in Human Genetics (McGill University). During her five years in the lab, she was involved in several projects on high grade astrocytomas and ATRTs, where she developed expertise in DNA next-generation sequencing and DNA methylation array analysis, but also in molecular cell biology (RTK trafficking). She is now in Melbourne, Australia where she combines work as a Clinical Fellow in pediatric oncology at the Royal Children's Hospital and as a post-doctoral Research Fellow at the Murdoch Children's Research Institute.

Jeremy Schwartzentruber, PhD

Jeremy was in the Jabado lab from 2011 to 2013. Coming from a computer science background, he got an exciting start in genetics when he worked on data from some of the first glioblastoma exomes. His work was key in the discovery of recurrent mutations in the histone H3 gene (H3F3A) at two positions: lysine 27 and glycine 34, which was published in Nature at the start of 2012. That led to a continued trajectory of interesting work discovering alterations of epigenetic modifier genes in different pediatric brain cancers. During the period 2010-2013 he also worked as a bioinformatician for the Canada-wide project FORGE - Finding Of Rare disease GEnes, which has now become Care4Rare. Jeremy left these projects in 2013 to begin a PhD at the Wellcome Trust Sanger Institute in Cambridge, UK, completed in 2017. He is now a postdoc at the European Bioinformatics Institute in Cambridge, UK, working on fine-mapping causal variants for Alzheimer's and Parkinson's diseases, although he does his computational work remotely from Falmouth, Cornwall.

Margret Shirinian, PhD

Margret began her post-doctoral fellowship in Jabado lab in 2009 where she studied Pilocytic Astrocytoma (PA) which is a common brain tumor in children, but poorly studied in the adult setting due to its rare incidence. By combining whole chromosomal copy number analysis and gene expression profiling, she identified non-random aneuploidy occurring in adult PA tumors which had distinct gene expression profiles. She is currently an Assistant Professor in the Department of Experimental Pathology, Immunology and Microbiology at the American University of Beirut. The research group she leads uses a fly model to study genes and molecular pathways implicated in development of brain tumors particularly focusing on epigenetic regulators and their role in central nervous system development.

Xiaoyang Liu, MD, PhD

Xiaoyang’s tenure in Jabado lab spanned between 2009 and 2012 where she completed her PhD studies as part of the combined MD-PhD program at McGill University. Her doctoral thesis aimed at unraveling the genetic and molecular pathogenesis of pediatric and young adult glioma. She is currently completing her residency in the Department of Radiology at the University of Toronto.

Karine Jacob, PhD

Karine carried out her PhD studies in the Jabado Lab between 2006 and 2011. She has the great distinction of being the first PhD graduate from the lab. During her graduate studies, she worked on elucidating the genetic landscape of pediatric low-grade and high grade astrocytomas using SNPs arrays. She subsequently did her training in Molecular Genetics under the auspices of the Canadian College of Medical Geneticists at McGill University. She presently works as a certified Molecular Geneticist. Outside work, she enjoys running and cross-country skiing.

Takrima Haque, PhD

Takrima was fortunate to be the first PhD student ever to join the Jabado Lab and witnessed first hand how the lab evolved over the years. She admits that it took her a while to complete her graduate studies, owing in part to two maternity leaves she took for the birth of her two children. She is presently working as a research assistant at the Centre de Recherche du Centre Hospitalier de l’Université de Montreal.

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